Bioscience seminar series

  • Datum: –09.30
  • Plats: Biomedicinskt centrum C4:2 Seminar room
  • Föreläsare: Christian Broberger, Prof., Dept. of Biochemistry and Biophysics, Stockholm University
  • Arrangör: Farmaceutisk Biovetenskap
  • Kontaktperson: Anna Nilsson
  • Seminarium

Anger Management: Hypothalamic Regulation of Aggression in Male and Female Mice

Social behaviour, including aggression, is a core feature of most animals, including humans. In recent years, the central network that underlies aggression has begun to be elucidated. We have identified a group of neurons in the ventral premammillary nucleus ("PMv-DAT cells") as an early node in the organization of intermale aggression. The intrinsic properties and wiring of these cells help explain why aggression outlasts the presentation of a stimulus (i.e. "why are we angry for so long after a fight?"). PMv-DAT cells help generate the reward associated with aggression and also play a key role in determining social hierarchies among male mice. In recent work, we have addressed the role of PMvDAT cells in female mice and discovered that this network is normally dormant but activates following the birth of offspring to drive maternal aggression.